The Mechanism of the Iodane‐Guided ortho C−H Allylation Unveiled

This work is the result of a joint collaboration of the DiMoCat group with the groups of with groups of Prof. A. Shafir of the Institute for Advanced Chemistry of Catalonia, Prof. A. B. Cuenca of the Químics de Sarrià, Prof. S. Lethu of the Institute of Chemical Research of Catalonia, and Prof. J. Zhu from Xiamen University. Our group has performed the DFT mechanistic study with a great work by Dandan Chen.

A metal‐free C−H allylation strategy is described to access diverse functionalized ortho‐allyl‐iodoarenes. The method employs hypervalent (diacetoxy)iodoarenes and proceeds through the iodane‐guided “iodonio‐Claisen” allyl transfer. The use of allylsilanes bearing electron‐withdrawing functional groups unlocks the functionalization of a broad range of substrates, including electron‐neutral and electron‐poor rings. The resulting ortho‐allylated iodoarenes are versatile building blocks, with examples of downstream transformation including a concise synthesis of the experimental antimitotic core of Dosabulin. DFT calculations shed additional light on the reaction mechanism, with notable aspects including the aromatic character of the transition‐state structure for the [3,3] sigmatropic rearrangement, as well as the highly stereoconvergent nature of the trans‐product formation.

Chen, W. W.; Cunillera, A.; Chen, D.; Lethu, S.; López de Moragas, A.; Zhu, J. Solà, M.; Cuenca, A. B.; Shafir, A. “Iodane-Guided ortho C-H Allylation” Angew. Chem. Int. Ed. 2020,  DOI: 10.1002/ange.202009369

 

A Review on Mechanistic Studies of Transition-Metal Catalyzed [2+2+2] Cycloaddition Reactions

The development of catalytic methodologies involving the formation of C-C bonds to enable the generation of cyclic systems constitutes a field of great relevance in synthetic organic chemistry. One paradigmatic process to accomplish this goal efficiently is the transition-metal catalyzed [2+2+2] cycloaddition reaction since it permits the formation of a wide range of highly functionalized six-membered carbo- and heterocyclic molecules in a single step with high efficiency and perfect atom economy. A key feature of these transformations is the mechanistic pathway that they follow, since a deep knowledge of this mechanism may enable us to understand and improve the efficiency of the reaction. This review covers the mechanistic aspects, studied both from theoretical and experimental points of view, of the transition metal-catalyzed [2+2+2] cycloaddition reaction involving all kinds of unsaturated substrates with metals such as Co, Ni, Ru, Rh, Ir, Pd, Zr, Ti, Ta, and Nb. A thorough overview is undertaken, from the seminal studies until the present day, of the key mechanistic aspects that influence the reactivity and selectivity of the reaction, comparing the involvement of different unsaturated substrates as well as the different transition metals used.

The review contains 86 pages, 6684 lines of text, 57971 words, 141 schemes, 9 Figures and 403 references. It has been reviewed by four referees who asked the authors to answer 210 remarks in the first round of peer-review and 46 in the second one. It has been a hard work and a long trip. Congratulations to Anna, Anna, and Miquel!

A. Pla-Quintana*, A. Roglans* and M. Solà*.

Mechanistic studies of transition-metal catalyzed [2+2+2] cycloaddition reactions.

Chem. Rev., 2020, DOI: 10.1021/acs.chemrev.0c00062.